WHAT DOES ISORHAMNETIN-3-O-GLUCOSIDE MEAN?

TAK-243 preferentially bound to UBA1 over the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lessened amounts of ubiquitylated proteins, enhanced markers of proteotoxic worry and DNA problems strain. In vivo, TAK-243 diminished leukemic load and targeted leukemic stem cells without evidence of toxicity.